Authorities said the truck was changing tires on the side of the road when the bus hit it in the Malawi city of Minya province, about 220 kilometers (137 miles) south of Cairo.
Ambulances rushed to the scene to transport the injured to hospitals in Minya. Images from the scene released by local authorities showed a bus with severe damage to the front half, apparently from colliding with the rear of the truck.
Road accidents kill thousands each year in Egypt, which has a poor record for transportation safety. Accidents are mainly caused by speeding, careless driving, bad roads, or poor enforcement of traffic laws.
In January, at least 16 people were killed and 18 others injured when a minibus collided with a public transport bus in the Sinai Peninsula. In April last year, a bus overturned while trying to overtake a truck on a highway in the southern province of Assiut, leaving at least 21 dead and three injured.